MAGE-D1 Regulates Expression of Depression-Like Behavior through Serotonin Transporter Ubiquitylation

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MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation.

The ubiquitin-proteasome system (UPS) controls the stability of most cellular proteins. The polymorphism of UPS-related genes is associated with major depression disorder, but less is known about the molecule that plays a role in depression by modulating the UPS. Melanoma antigen gene-D1 (MAGE-D1) interacts with RING E3 ubiquitin ligase and is implicated in protein degradation. MAGE-D1 may thus...

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Correspondence to: Vjekoslav Peitl, MD Psychiatric Clinic Sestre Milosrdnice University Hospital Vinogradska Cesta 29, 10000 Zagreb, Croatia Tel/fax: +385 01 3787 742, email: [email protected] Copyright © 2015 KBCSM, Zagreb e-mail: [email protected] • www.http//hrcak.srce.hr/acoholism Abstract – Serotonin is regarded as one of the most important factors in modern psychiatry and...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2012

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.6458-11.2012